My family and I are looking into buying a poodle and beginning to breed doodles. Our plan at this point is to buy a female standard poodle and cross breed her with different males to offer a variety of crosses. Some of the crosses, however, do pose a size difference. I am looking at Bernese Mountain dogs, Great Pyrenees, Great Danes and St. Bernards, but I'm just wondering if she would be able to handle males that size? I have read that the more puppies she has per litter the smaller each puppy will be, and she'll have a better chance of a natural birth. I'm just not sure it's worth the risk, though, and I'm trying to do my research now before buying a bitch and building a breeding plan around something which may not be possible. I just don't know if it's that big of a difference of not? I wouldn't be breeding a Chihuahua to a Rottweiler, but I'm still hesitant about the difference in their weight and build. Thank you for any input!