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Regenerative anemia help

Discussion in 'Dog Health and Nutrition' started by AdamJ1901, May 15, 2017.


  1. AdamJ1901

    AdamJ1901 PetForums Newbie

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    My baby is a boxer, 5 1/2 years old, male, fixed.

    Health history: 3 months ago he got pretty sick, fever got up to 106, vet gave him a shot of antibiotics and his fever dropped. A couple days later he was back to normal. He was anemic then, but they figured it was due to him being sick. About a month ago he seemed to be in quite a bit of pain, extremely lethargic, not wanting to move, eat, drink. Took him to the vet and the vet examined his back and noticed his back muscles would spasm when he pet over his back. He decided my dog had hurt his back and gave him some anti inflammatories / muscle relaxers. 2 days later he was back to normal, but we drew his blood work during that time and he was pretty anemic at about 23%. He put him on an antibiotic an his anemia improved some, up to 28%, but his platelet count dropped a little, and his lymphocyte count jumped. He said this being a bacterial cause would be unlikely at this point as he would show some signs or symptoms. He obviously knows more than I do, but it looks like the antibiotic helped some, and mildly pissed off whatever is in his system due to the lab work changes. Any insight would be great.

    I'm just a paranoid dog owner. The vet referred me to a medicine internist since we ruled out a tick borne disease (i think we ruled out lymes), auto immune disease, and really anything else they could diagnose there. I can't get him into the internist for another week. He doesn't show any signs or symptoms other than increased respirations. He still eats, maybe drinks a little more water than normal, he still plays when he wants, still tries to steal my food, so im just trying to get a head start on what to feel before I go to the internist. I know cancers are more common in boxers, so I am trying to prepare for that. Any home remedies to help improve the anemia while I wait would be wonderful, or any possible thoughts on the blood work. My vet was thinking they will want to do a bone marrow biopsy, but that's really about as much as he mentioned. Personally, I feel it is still bacterial related from the blood work differences. I will link his blood work here. The values on the far right were before the vet gave him Orbax (an antibiotic 100mg daily for 1 1/2 weeks). The values on the left are after the antibiotic.
    Thanks for taking the time to read this. I am wondering what anyone else may think that might ease my brain, or give me more ideas before I go to the internist.
     

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  2. Sled dog hotel

    Sled dog hotel PetForums VIP

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    I know there is auto immune haemolytic anemia where the body starts to produce antibodies against its own red blood cells, but as you say that seems to have been ruled out, and that normally responds like most other auto immune diseases to high dose immunosuppressant drugs usually steroids.

    There is secondary immune hemoytic anemia which is caused by other underlying things/llnesses that you say some of which has been ruled out? but there are others too. You mentioned lymes has been tested and ruled out but there are also other tick borne diseases especially if you are not in the UK, although having said that there have been cases in the last year at least of dogs being infected by tick borne diseases not normally found in the UK too.
    If its responded or seemed to respond to antibiotics at least for a while then it does sound like it is more likely to be secondary and there is another underlying cause, quite possibly infection and an infection that has got to respond to antibiotics so therefore something that could be bacterial, or logically thinking anyway.

    I have managed to find this article on immune mediated haemolytic anemia written by vets and peer reviewed. If you scroll down there is a table of causes of secondary immune mediated haemolytic anemia, which is split into types of secondary IMHA, the first is infectious causes, then Toxin or drug related and so on. So you can check on there infectious causes some of which are bacterial and more about the condition and treatment in general.

    One thing though under infectious that I did spot especially as you mentioned a problem with his back and back pain too, there is something called diskospondylitis mentioned which is back/spinal problem. On checking diskospondilitis it turns out it is an infection of the vertebrae and intervertebral disc spaces and it occurs more commonly in young to middle aged dogs (admittedly not how young) but more in males and medium to large breeds, and its caused by bacteria, and needs 8 weeks minimum of antibiotics and obviously the correct ones according to the info. Symptoms are fever, lethargic, off food etc and pain in the back/spine, if like the other article on the secondary causes of hemolytic anemia says too it can be a cause of secondary immune mediated anemia may be a possible perhaps. Both articles are written by vets in fact specialists so should be reliable sources of information.

    The full article on Immune mediated haemolytic anemia including the table of secondary causes is on this link for you to read
    http://vetfolio.s3.amazonaws.com/5a...harp-immune-mediated-hemolytic-anemia-pdf.pdf

    The full article on diskospondylosis is on this link
    http://www.theanic.com/uploads/4/7/1/6/47161877/disco.pdf

    Hope this may be some help in your search for information.
     
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  3. AdamJ1901

    AdamJ1901 PetForums Newbie

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    diskospondylosis is something I had not came across yet, but does fit a good portion of the signs and symptoms. Today is the first day he's had an "off day" in a while. He threw up some foam in the early morning, and isn't interested in his breakfast. His appointment with the medicine internist is in two days, hopefully he can rebound long enough that we can make his appointment time and I don't have to go through their ER.
     
  4. Sled dog hotel

    Sled dog hotel PetForums VIP

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    Whats his gum colour like if his gums are very pale and especially white then that's a sign his red blood cell count has dropped and he is anaemic. They will usually have a high respiratory rate even when resting, almost like you would expect more after exercise. This is because red blood cells carry oxygen around the body, and when the count is low it shows as more exertion in their breathing They do go off food too. If he has had a relapse and showing all these signs I wouldn't leave it another two days, I would check in with your normal vet at least and tell them what is happening they may need to re-check his red blood cell count and see if its really dipped, if it is going lower and lower and gets too low he is really going to be in trouble.
     
  5. AdamJ1901

    AdamJ1901 PetForums Newbie

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    His gums are pink-ish. His resp rate seems about normal which I find odd because I know he is anemic, but its been roughly two weeks since his last blood draw because that is when they referred me out. He was at 28% then, up from 23, but he's no longer on the antibiotics that contributed (or seemed to contribute to the slight improvement). He still gets up to bark at things. I still have some of his muscle relaxing medication, and im debating giving him that in case it is something wrong with his back to make him more comfortable for the time being, and maybe it'll make him feel better enough to eat some of his breakfast. The facility I'm going to take him to does not have any sooner appointments with a medicine internist, and basically said I can bring him through the ER, but he's going to see their ER doctor and not an internist that way. His appointment is in less than 48 hours. If it doesn't get any better I will have no choice but to take him through the ER route while keeping his appointment for Thursday.
     
  6. Sled dog hotel

    Sled dog hotel PetForums VIP

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    If he is no longer on antibiotics and it is secondary IMHA due to some kind of bacterial infection may be even discospondylitis then that may be why you are starting to get a relapse and signs of symptoms again. it may have started to get on top of the infection hence the lessening of symptoms but now off them what ever the bacterial infection is its beginning to increase again. It does say on that literature discospondylosis needs a minimum of 8 weeks continuous antibiotics. Having lost a dog to low red blood cell count and serious anemia at a GP vets who didn't do a refferal, if the RBC is waning it can happen quickly, mine went from normal to very ill in 48 hours and I lost him. The day he went in they did repeat RBC counts and they were just dropping and dropping. It also has to be the right sort of antibiotics as well as a long enough course too. That article on IMHA is from is under a Emergency and critical care medicine heading. If he is relapsing at least the ER will start working on it sooner then waiting for the appointment in two days time.
     
  7. AdamJ1901

    AdamJ1901 PetForums Newbie

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    If his resp rate was increased even further I would assume the anemia has become more severe, as that is the first way your body tries to get more oxygen (increased heart rate, increased resp rate), but if anything his resp rate is better than it has been. He was good yesterday, he stole the loofah from the shower and shredded it, but he only had it for a few seconds time. Not sure if that could contribute to what I'm seeing here, but since I know he is already sick I highly doubt it. Gonna try some ground beef and rice a little later and see if he will eat that. Other than this he has held up well waiting for his appointment, so I am trying not to under react or over react. Thank you for your input too, I really do appreciate it.
     
  8. Sled dog hotel

    Sled dog hotel PetForums VIP

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    Maybe just monitor him and keep an eye on his respiratory rate and gum colour, and obviously if he starts to become more lethargic and weak then you will then have to perhaps think about going to the ER sooner then later. I hope you can get to the bottom of whats causing it soon, and get the proper treatment. Please keep us updated how he is doing.
     
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