Hi, I posted yesterday about a new cat I have now had for about a fortnight, she is a two year old Siamese. We had her from a rescue centre where she was only there a couple of days, at her old home she had a litter of kittens but was spayed some months ago. She seems to have been well looked after, she is a good weight and all her vaccinations are up to date, we even had an email passed on to us from her previous owner asking how she was and enclosing some cute photos. The reason we are told she was re-homed is because her previous owners had three other cats which she would constantly attack. Since we had her she has been really affectionate although a bit skittish, , she sleeps under the duvet, she will come and lie with us whilst watching TV and always follows us around the house miaowing (as siamese do) but if there's a knock on the door or a loud bang she will run off and hide for a short while. Last night we got home from work and she ate her tea fine and was acting perfectly normal, we nipped to the gym for an hour and when we got back it was like she had gad mad. Her eyes were massive, she was tearing around everywhere, constantly biting herself and breathing really fast. As the night wore on things got worse she would stop for a while and sit down but her back would start tensing and rippling then her tail would start flying all over the place and she would constantly bite her back and tail so hard it was making her yelp if we tried to calm her down or stroke her she would bite us instantly (she has never even looked like biting us before). I was really worried so we phoned the out of hours vet service who said to leave her alone to settle down and if things didn't improve to bring her in or in any case take her in in the morning. I also took a look on the internet (I know we perhaps shouldn't but we all do) and found out about something called feline hyperesthesia which I hadn't heard of but appeared to fit exactly with the behaviour she was portraying and it is said Siamese are more prone than other breeds. In the early hours she did seem to settle a bit, she was hidden under the bed but didn't seem to be too distressed. Early this morning she came to lie with me in bed, she was constantly licking her entire body for hours and still occasionally attacking her tail but I covered her back end with the duvet and she settled down a bit although she didn't sleep at all. When we got up this morning it all started again and she was back biting her tail and running around manically, she wouldn't touch her food but ate a couple of dreamies and I saw her take a small drink. We took her to the vets and the vet examined her and could see no obvious physical cause. As is sods law when we got there she had stopped the back rolling and biting and was just cowering and obviously very scared (I hope we did the right thing taking her). We had treated her with Stronghold a week ago so the vet said that fleas were unlikely. We were told that as she was obviously quite nervous by nature and the symptoms may be some kind of defense mechanism to cope with the anxiety she has suffered with changing homes and being at a rescue centre etc. We were told to install a Feliway diffuser which we have done and just monitor the situation to see if she would settle down. When we got home she seemed a bit scared and ran and hid under the bed, I have had my girlfriends parents come round to keep an eye on her whilst we are at work. They have told me she stayed under the bed for a couple of hours but came out and had a small amount of food and came to them for some attention but within about 10 minutes her back started twitching and she started biting herself again and quickly ran off to hide under the bed. We are beside ourselves with worry, we have only had her a short while but she has quickly become one of the family and we both really love her. Has anybody else experienced anything similar and did things get better? She just appears so distressed and we feel so useless we really don't know what to do and how we can make things better for her.