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Border Collie UK Epilepsy Study

Discussion in 'Dog Health and Nutrition' started by AJ, Aug 7, 2008.

  1. AJ

    AJ Guest


    Canine Epilepsy Studies at the Animal Health Trust Scientists and
    clinicians at the Animal Health Trust (Animal Welfare, Cat, Dog, Horse, Charity, Donations, Animal Health Trust) are embarking on
    an exciting project to investigate the genetic basis of epilepsy in the
    Border Collie. By combining the expertise of the clinicians to
    diagnose dogs with idiopathic epilepsy and state of the art genetic
    research capability we hope to identify the genetic factors that
    influence a Border Collie's risk of developing epilepsy.

    If the research is successful the end product will be a DNA test that
    can identify any Border Collie's risk of developing epilepsy and passing
    it on to future generations.

    If you have a Border Collie that is either:
    a) Affected with idiopathic epilepsy
    b) Closely related to a dog that is affected with idiopathic
    c) Unaffected with epilepsy and over 7 years of age
    please consider donating a DNA sample to this research project.
    Many Thanks
    Luisa De Risio, DMV, MRCVS, PhD, DECVN,
    European and RCVS recognised specialist in veterinary neurology
    Neurology/Neurosurgery Unit
    Centre for Small Animal Studies
    Cathryn Mellersh, PhD
    Department of Genetics
    Centre of Preventive Medicine

    DNA Testing- Contact Us
    General Enquiries: dnatesting@aht.org.uk

    Requests for swab kits: swab.request@aht.org.uk

    Telephone: +44 (0)8700 509144

    Fax: +44 (0)8700 502461

    Address: Genetic Services, Animal Health Trust, Lanwades Park, Kentford,
    Newmarket, Suffolk CB8 7UU.
  2. Jenny Olley

    Jenny Olley PetForums VIP

    Nov 2, 2007
    Likes Received:
    Interesting post Alan, I shall pass it round to people that have BC's and may be able to help.
  3. tarot

    tarot PetForums Junior

    Feb 19, 2008
    Likes Received:
    I think this is the same study I sent dna samples to last year. The pack consisted of 3 seperate packs, 1 for each dog and it was very easy to take the samples and did not seem to bother the dogs in the slightest. I have 2 collies who suffer with epilepsy, the youngest who started fitting at 2 and has severe attacks, is not related to the others. Tarot and Acer are related and Acer started fitting last year when he was 7. Luckily Tarot at 12, does not appear to be affected. If these studies help to identify carriers of epliepsy it can only be good for the breed. Unfortunatley Acer came from show lines and his relatives as far as I am aware are still being used at stud.
    Perhaps if this report shows the lines that carry epilepsy it may help stop puppies being bred with it.

  4. spellweaver

    spellweaver Guest

    Very interesting Alan - anything that stops something like this has got to be good. As far as I know (which isn't very far, I must admit! :rolleyes:) our lines are OK - I'll check with Carol and Jean.
  5. AJ

    AJ Guest

    Research into additional canine inherited conditions is ongoing at the Animal Health Trust, including:
    • Primary lens luxation in terrier breeds (in collaboration with David Sargan (University of Cambridge) and David Gould (Davies Veterinary Specialists)
    • Sebaceous adenitis in Standard Poodles,
    • Cerebellar ataxia in Italian Spinones.
    • Multifocal Retinal Dysplasia in Golden Retrievers
    • Idiopathic epilepsy in Border Collies
    AHT are also collecting samples from dogs of other breeds affected with any of the conditions listed above.


    Below are some questions that will help you determine whether your dog can contribute to the AHT’s inherited disease research and assist with the development of a diagnostic test in your breed:

    Q. Which dogs can contribute to the AHT’s research

    A. There are two types of dog that are useful to our research:
    • Any dog of any breed that has been diagnosed as AFFECTED with any of the conditions under investigation.
    • Close relatives of affected dogs. By close relatives we mean parents, siblings or grandparents
    Q. If my dog falls into either of the categories listed above can I contribute to the AHT’s research?

    A. We need a sample of your dog’s DNA. The DNA can be extracted from a small blood sample collected by your vet at any time when your dog is having blood drawn for any other purpose, or as a buccal (cheek) swab that you can collect yourself.

    Q. My dog can help your research – what do I do next?

    A. Request a DNA sampling pack from the AHT by contacting Bryan McLaughlin
    The pack contains: 2 buccal swabs, Instructions for the successful collection of DNA, A Sample Submission Form for you to sign confirming the AHT can use your dog’s DNA for genetic research. This form also contains instructions for your vet if you choose to submit DNA as a blood sample and information about where to send the swabs/blood, pedigree and health information.
    Once research into a particular inherited condition is complete, and a DNA test has been developed, we happily provide the results of any dogs that were used in the research, free of charge, to that dog’s owners upon request. The dogs we use in individual studies varies; sometimes we will use all dogs from an extended pedigree whereas sometimes we will only use affected dogs and their parents. Our choice of dogs depends on several factors, including the nature of the disease and the samples that we have available.
    If you have any further questions please contact AHT.
  6. spellweaver

    spellweaver Guest

    The AHT do some excellent work. As well as the above, they also do the following, copied from their website:

    Animal Welfare, Cat, Dog, Horse, Charity, Donations, Animal Health Trust

    Hereditary Cataract & Progressive Retinal Atrophy
    Funded by the Kennel Club Charitable Trust the canine genetics team are now involved in an exciting project to study the genetics of Hereditary Cataract (HC) and Progressive Retinal Atrophy (PRA) in the Golden Retriever, the American Cocker Spaniel and the Tibetan Spaniel.

    We aim to identify the genetic mutations that are responsible for HC in the Golden Retriever and the American Cocker Spaniel and for PRA in the Golden Retriever and the Tibetan Spaniel. We will develop DNA diagnostic tests that breeders can use to eliminate these debilitating diseases from their breeds.

    In addition to the 3 breeds listed above we are also investigating the genetics of HC in Australian Shepherds, Siberian Huskies, Large Munsterlanders and any other breeds for which we can collect sufficient DNA samples.

    The success of this research will largely depend on the successful collection of DNA from dogs that can usefully contribute to our research. All research is carried out in the strictest confidence and we do not share genetic information about any dog with anybody except that dog’s owner.
  7. Cazmatch

    Cazmatch PetForums Member

    Sep 10, 2008
    Likes Received:
    I had a St Bernard who died recently due to Epilepsy, so I hope the study goes well.
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