i just thought you had to test weather the parents was clear or not?? now i am confused(

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Why Dont You Go Peddle Crazy Some Place else As We Are All Stocked Up Here

No Garry,if the pup/dog is from untested parents or a clear was mated to a carrier then you need to test.

This is how it works,
CLEAR: the dog has 2 copies of the normal gene and will neither develop L-2-HGA, nor pass a copy of the L-2-HGA gene to any of its offspring.

CARRIER: the dog has one copy of the normal gene and one copy of the mutant gene that causes L-2-HGA. It will not develop L-2-HGA but will pass on the L-2-HGA gene to 50% (on average) of its offspring.

AFFECTED: the dog has two copies of the L-2-HGA mutation and is affected with L-2-HGA. It will develop L-2-HGA at some stage during its lifetime, assuming it lives to an appropriate age.

Carriers can still be bred to clear dogs. On average, 50% of such a litter will be clear and 50% carriers; there can be no affecteds produced from such a mating. Pups which will be used for breeding can themselves be DNA tested to determine whether they are clear or carrier

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Rooney Rumpus DNA Tested L2/HC Clear

Ellies Babe Genetically L2/HC Clear

ruardeanstaffords

oh ok then

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Why Dont You Go Peddle Crazy Some Place else As We Are All Stocked Up Here

Just to add AFFECTED DOGS should NEVER be bred from,I don't believe we should be breeding from Carriers either.

Tylers Sire (Trooper) was a Carrier and his owner had him castrated,such a shame he was a lovely dog.We were hoping that his Breeder would do a repeat mating,but that's never going to happen.

His Parents were Eye Tested clear and we were gobsmacked when we were told his sire was a Carrier for L2,so we were on a knife-edge for 3 weeks till we got his results back,if he had been a carrier he would have been castrated too.

His Dads picture is here sharoc06

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Rooney Rumpus DNA Tested L2/HC Clear

Ellies Babe Genetically L2/HC Clear

ruardeanstaffords

great dog,yeah you can see the likness to your tyler

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Why Dont You Go Peddle Crazy Some Place else As We Are All Stocked Up Here

I am pleased that the tests are clear.

I have seen on previous threads potential owners should check out any hereditary health problem. If I don't ask I will never know, what is L2, HC and PHPV.

All I have ever checked for is a wet nose, glossy coat and wagging tail. A pot belly usually meant they needed worming.

Sue

Hi Sue,
This should explain,

1. L-2-HGA Hydroxyglutaric Aciduria

In the past few years a small number of Staffords have been diagnosed with a metabolic disorder, its clinical name is L2 hydroxyglutaric aciduria or L-2-HGA. This condition manifests itself in varied ways with affected dogs displaying behavioural changes and dementia, anxiety attacks, having full blown seizures, as well as exercise intolerance and ataxia (unsteady gait), tremors and muscular stiffness. Dogs from totally different bloodlines have been found to be sufferers and the number of affected dogs diagnosed has risen. The disorder (and a similar linked disorder D-2 HGA) is found in humans, again very rare, but nevertheless devastating for those families affected by it. The disorder has an autosomal recessive method of inheritance, which means that both parents must be carriers of the affected gene to produce affected offspring.

Through excessive hard work not only on behalf of the Animal Health Trust at Newmarket and by people submitting blood and urine samples from the families of affected animals a genetic test has been determined to identify the carriers of the gene which causes L-2-HGA.

IT IS THEREFORE ADVISABLE THAT ALL BREEDING STOCK BE SCREENED IN ORDER TO ERADICATE THIS CONDITION IN THE FUTURE.


TESTING CAN TAKE UP TO 6 WEEKS FOR RESULTS SO PLEASE MAKE SURE YOU HAVE THIS DONE IN PLENTY OF TIME BEFORE YOUR PLANNED MATING.


2. HC – HEREDITARY CATARACTS.

It is known that HC is inherited by and automal recessive path (i.e. both parents must be carriers of the defective gene to produce and affected offspring). HC is a progressive condition and this means that although a puppy is not born with cataracts they will start to develop at a juvenile age. (maybe from 8 months onwards), and will progress until the dog is totally blind. This condition is bilateral which means is affects both eyes equally. Thanks to the tireless research by the Animal Health Trust in Newmarket there is a now a DNA Test for Hereditary Cataracts.

3. PHPV – PERSITENT HYPERPLASTIC PRIMARY VITREOUS

The mode of inheritance of PHPV is not so clear, but it is known that it is a congenital condition (present at birth) and that it is not progressive. This means that if a puppy is born with PHPV it can be detected by ophthalmic screening from 6 weeks of age and if it is affected, whatever the condition of the problem at that stage it will not change throughout the dogs life.

Either of the above conditions can be operated on, but it is a serious operation and can be traumatic and very expensive. It is not always covered by insurance due to the hereditary nature.

Even though the genetic test is now available for Hereditary Cataracts it is still important to screen for PHPV.

4. PPSC – POSTERIOR POLAR SUBCAPSULAR CATARACT.

This type of cataracts is found in other breeds, particularly the Labrador and Golden Retriever.
It usually remains as a small, punctuate cataract and doesn’t usually lead to sight problems in these two breeds. It has been placed on schedule 3 of the BVA/KC/ISDS Eye Scheme because a number of Staffords that have been through the Scheme have been found to have this type of cataract. This type of cataract cannot be detected through litter screening. The mode of inheritance is unknown and has a variable age of onset. BREEDING STOCK SHOULD BE TESTED ANNUALLY TO DETERMINE THAT THE DOG IS CERTIFIED CLEAR AT THE TIME OF MATING.

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Rooney Rumpus DNA Tested L2/HC Clear

Ellies Babe Genetically L2/HC Clear

ruardeanstaffords

Thank you Sallyanne I understand the importance now and exactly what it means.

Breeding isn't something I want to do, but its really useful information and something I wasn't aware of until I joined this forum.

It must be a fantastic feeling when you are considering breeding and the results are clear.

Sue