I had both my giant bunnies done recently as they were brother and sister. I didn't want getting preggers so we had him done first and she's a right stroppy one so that's why we had her done. Had no probs and they're both fit and well.
I used to breed mini lops and found my mini lop bucks were a pain once they were used to being a stud. They used to try and hump everything - the cat, me, carrier bags. Not sure if they're all like this.