We have four cats but when we lost Paddington last year it did affect the others slightly,they looked for him for a day or two but got over it suprisingly quickly. They were more affected when the dog died, it took weeks for them to stop looking for him. It really depends how close your two cats become, two of ours are best buddies but they probably wouldn't notice if the other two dissapeared off the face of the earth. Not being very helpfull am I

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