I had this problem with my rabbit. She got to about 6 months old and her temperament changed. She wouldnt let me touch her at all. It was almost overnight that the change in her happened. I had her spayed and what a difference! She is back to her old self. Still has her moments but females do! They are prone to cancer too so best all round to have her done. Good chance to get her teeth trimmed whilst she's under as they suffer terrible problems if their teeth grow too long.