Thank you both for your replies.
I've decided not to use it.....ever again, but i'm struggling to find another toothpaste to use. I've read about PetzLife, I don't like the ingrediants I read about in this either and then I was thinking about Logic Gel, I can't find a full list of ingrediants for this, but I think it might contain Hydrogen Peroxide. Does anyone use Logic Gel and if so, would you be able to list the ingrediants for me.
I was reading a little into the Sodium Benozate myself, if your a serious worrier, like me, you probably know that searching on the internet usually makes you worry more (which it did)
This is what I found:
Quote:
Oral exposure
In general, the database for benzoic acid and sodium benzoate is limited, and there are no studies available performed according to current guidelines. In addition, the documentation of these studies in most cases is insufficient. Detailed information is given in Table 3.
From the available studies, it can be assumed that the toxicity of benzoic acid after short-term oral exposure is low. In high-dosed rats given approximately 2250 mg/kg body weight per day via diet over 5 days, excitation, ataxia, convulsions, and histopathological changes in the brain were seen. The mortality was about 50%; in some cases, bleeding into the gut was noted (Kreis et al., 1967). In two other studies with rats dosed with approximately 825 mg/kg body weight per day over 7-35 days (Kreis et al., 1967) or with 65-647 mg/kg body weight per day over 28 days (Bio-Fax, 1973), no clear treatment-related effects occurred. The reduced weight gain at 2250 and 825 mg/kg body weight per day may be attributed to reduced food intake in the study by Kreis et al. (1967). The relevance of the reduced relative kidney weight at 324 mg/kg body weight per day, which was not dose-related and not accompanied by changes in histopathological examinations, is unclear (Bio-Fax, 1973). As given in Table 3, both studies have several limitations (i.e., missing haematological and clinical chemical investigations, incomplete histopathological examinations); therefore, both of these studies were inadequate for derivation of a NO(A)EL.
More information on dose-response can be gained from the study of Fujitani (1993), in which rats received sodium benzoate for 10 days i feed. At the lowest tested concentration of 1358 mg/kg body weight per day, changes in serum cholesterol levels occurred in females. At doses of 1568 mg/kg body weight per day and above, changes in further serum parameters and an increased relative liver weight were described. Histopathological changes of the liver, increased relative kidney weights, and disorders of the central nervous system (convulsions) were seen after dosing via diet with approximately 1800 mg/kg body weight per day. In several other studies listed in Table 3, adverse effects were seen only at higher doses after feeding sodium benzoate over periods from 10 to 42 days, so that a lowest-observed-(adverse-)effect level (LO(A)EL) of 1358 mg sodium benzoate/kg body weight per day for short-term exposure can be derived.
With cats (Bedford & Clarke, 1972), also described in Table 3, the effect levels with benzoic acid were lower. However, due to the differences in the metabolism of benzoic acid in cats compared with other experimental animals and humans, this study was not taken into further consideration (see section 7).
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This is the information from the table which shows some results:
Quote:
4 male cats had 0 or 0.5% in their diet or (approx. 0 or 300-420 mg/kg body weight) over 3-4 days.
Organs which were examined are the liver, kidney, heart, stomach, lung, brain, spinal cord (only animals that died were examined); blood samples were taken from surviving cats.
The findings were mild hyperaesthesia, apprehension, and depression starting 48-92 h after uptake; duration of the syndrome: about 20-48 h; mortality rate: 50%; degenerative changes in liver, kidneys, and lung, but no pathalogical findings in brain or spinal cord; surviving cats: urea and serum alanine aminotransferase (S-ALAT) *, indicating liver and kidney damage.
Reference: Bedford & Clarke (1972).
(a) 4 male cats were also had 100 or 200 mg/kg body weight in their diet over 15 days, only blood samples were taken and no adverse reactions were reported.
(b) 0 or 0.25% in their diet (approx. 0 or 130 - 160 mg/kg body weight) over 23 days, only blood samples were taken and no adverse reactions were reported.
Reference: Bedford & Clarke (1972).
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Doesn't that work out that if a cat was an average 4kg, he would have had around 1200mg because of the 300 - 420 mg per kg body weight which is about 100 grams over 3-4 days. With a 70g tube of toothpaste, that would mean the whole tube would've been ingested and 30g more.
That is probably dependant on how much they put in a tube though, I may contact them about it, but they don't currently have an email address to enquire about these kind of things.
Have I worked that out correctly?
Thanks again.